Two recent studies uncovered the benefits of CBD oil with symptoms of depression.
In one study, conducted in 2011 while studying the modulation of the serotonin system through endocannabinoid signaling, researchers found “ample evidence that endocannabinoids are important regulators of stress responses.” Thus it can be assumed that, during depression, plant cannabinoids such as CBD have the ability to regulate one’s response to stressful situations.
Additionally, Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London observed that, at high concentrations, CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect.